Taha, Ai Yun; (2024) Resting State Functional Connectivity and Decision Making in Borderline Personality Disorder. Doctoral thesis (Ph.D), UCL (University College London).

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Abstract

Borderline Personality Disorder (BPD) is a complex mental health disorder with a myriad of difficulties, including dysregulation of self, emotions, behaviours and relationships. The complexity of BPD is further compounded by the presence of co-morbidities. Understanding such a complex disorder warrants the use of various frames of understanding and explaining. Specifically, there are merits in combining evidence-based clinical frameworks/treatment with the understanding of core deficits at a neural level using fMRI. This will allow us to better map and explain core BPD difficulties. In this PhD, the aim is to consider neural activity when the brain is at rest (commonly termed resting state functional connectivity) and when the brain is engaged in a task. This combination of theoretical framework and methodology will allow us to gain better insight into the core self-referential processing underpinning BPD. Firstly, the initial aim of this PhD is to investigate neural activity at rest, both at the local level and whole brain level. This will be followed by investigating the topological organization of the brain, at both the local and global level. Lastly, this PhD thesis will investigate decision making in BPD when participants are engaged in a multi-round bargaining game. Across all the research, associations with key indices of BPD symptomology will also be explored.

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