Waalewijn, Hylke;
Wasmann, Roeland E;
Bamford, Alasdair;
Gibb, Diana M;
McIlleron, Helen M;
Colbers, Angela;
Burger, David M;
(2024)
Population Pharmacokinetics of Dolutegravir in African Children: Results From the CHAPAS-4 Trial.
Journal of the Pediatric Infectious Diseases Society
10.1093/jpids/piae076.
(In press).
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Abstract
We characterized population pharmacokinetics in 42 African children receiving once-daily 25 mg (14 to <20 kg) or 50 mg (>20 kg) dolutegravir. Coadministration with emtricitabine and tenofovir alafenamide reduced dolutegravir bioavailability by 19.6% (95% confidence interval: 8.13%–30.8%) compared with zidovudine or abacavir with lamivudine. Nevertheless, concentrations remained above efficacy targets, confirming current dosing recommendations.
| Type: | Article |
|---|---|
| Title: | Population Pharmacokinetics of Dolutegravir in African Children: Results From the CHAPAS-4 Trial |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1093/jpids/piae076 |
| Publisher version: | http://dx.doi.org/10.1093/jpids/piae076 |
| Language: | English |
| Additional information: | © The Author(s) 2024. Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Infectious Diseases, Pediatrics, children, dolutegravir, HIV, pharmacokinetic, population pharmacokinetics |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10196772 |
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