Molinger, Jeroen;
Whittle, John;
Endeman, Henrik;
MacLeod, David;
Gupta, Rajan;
Fudim, Marat;
Haines, Krista L;
... Bakker, Jan; + view all
(2024)
A novel ultrasound approach in assessing IMAT in critically ill patients.
Frontiers in Anesthesiology
, 3
, Article 1458633. 10.3389/fanes.2024.1458633.
Preview |
Text
fanes-03-1458633.pdf - Accepted Version Download (10MB) | Preview |
Abstract
BACKGROUND: Muscle wasting is a common finding in critically ill patients associated with increased days of mechanical ventilation in the ICU. Muscle wasting and associated morphological changes are hallmarks of ICU-acquired weakness. Muscle wasting can be diagnosed and quantified by muscle biopsy, but biopsies can cause multiple adverse effects. MuscleSound® has developed a non-invasive, real-time novel MusculoSkeletal (MSK) ultrasound approach to measure the ratio between percentage intramuscular adipose tissue (%IMAT) with muscle cross-section area (MCSA) (termed IMAT-Index). The present study aimed to assess the IMAT-Index in ICU patients longitudinally and compare it to age-matched healthy controls. METHODS: Transverse (short-axis) ultrasound images of the rectus femoris muscle were obtained upon admission and discharge in 35 ICU patients and compared to age-matched healthy controls (n = 975). The echo intensity of the image taken from the muscle is used to automatically calculate the ratio between intramuscular adipose tissue by cm2 (IMAT-Index), the cross-sectional area of the muscle (MCSA), and muscle thickness (MT). RESULTS: IMAT-Index was successfully measured in all subjects. The mean IMAT-index (%IMAT/cm2) upon admission was significantly higher in critically ill patients compared to healthy controls (7.4 ± 4.3 vs. 3.1 ± 0.9, p < 0.001). At ICU discharge, the IMAT-index increased in the ICU group compared to admission (8.1 ± 3.5 vs. 7.4 ± 4.3, p < 0.05). CONCLUSION: Real-time noninvasive MSK ultrasound IMAT-Index was higher in ICU patients than in healthy controls and increased during the ICU stay, both in male and female patients.
| Type: | Article |
|---|---|
| Title: | A novel ultrasound approach in assessing IMAT in critically ill patients |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fanes.2024.1458633 |
| Publisher version: | https://doi.org/10.3389/fanes.2024.1458633 |
| Language: | English |
| Additional information: | © 2024 Molinger, Whittle, Endeman, MacLeod, Gupta, Fudim, Haines, Barkauskas, Healy, Wischmeyer and Bakker. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| Keywords: | IMAT intermuscular adipose tissue, muscle ultrasound, ICU acquired muscle weakness, muscle wasting, muscle weakneess, critical illness |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10196913 |
Archive Staff Only
 |
View Item |
