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Weakly Supervised Localisation of Prostate Cancer Using Reinforcement Learning for Bi-Parametric MR Images

Pocius, M; Yan, W; Barratt, DC; Emberton, M; Clarkson, MJ; Hu, Y; Saeed, SU; (2024) Weakly Supervised Localisation of Prostate Cancer Using Reinforcement Learning for Bi-Parametric MR Images. In: 2024 IEEE International Symposium on Biomedical Imaging (ISBI). IEEE: Athens, Greece. Green open access

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Abstract

In this paper we propose a reinforcement learning based weakly supervised system for localisation. We train a controller function to localise regions of interest within an image by introducing a novel reward definition that utilises non-binarised classification probability, generated by a pre-trained binary classifier which classifies object presence in images or image crops. The object-presence classifier may then inform the controller of its localisation quality by quantifying the likelihood of the image containing an object. Such an approach allows us to minimize any potential labelling or human bias propagated via human labelling for fully supervised localisation. We evaluate our proposed approach for a task of cancerous lesion localisation on a large dataset of real clinical bi-parametric MR images of the prostate. Comparisons to the commonly used multiple-instance learning weakly supervised localisation and to a fully supervised baseline show that our proposed method outperforms the multi-instance learning and performs comparably to fully-supervised learning, using only image-level classification labels for training.

Type: Proceedings paper
Title: Weakly Supervised Localisation of Prostate Cancer Using Reinforcement Learning for Bi-Parametric MR Images
Event: 2024 IEEE International Symposium on Biomedical Imaging (ISBI)
Dates: 27 May 2024 - 30 May 2024
Open access status: An open access version is available from UCL Discovery
DOI: 10.1109/ISBI56570.2024.10635642
Publisher version: http://dx.doi.org/10.1109/isbi56570.2024.10635642
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Training, Crops, Reinforcement learning, Labeling, Lesions, Task analysis, Prostate cancer
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery-pp.ucl.ac.uk/id/eprint/10197175
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