Wasserman, Sean;
Donovan, Joseph;
Kestelyn, Evelyne;
Watson, James A;
Aarnoutse, Robert E;
Barnacle, James R;
Boulware, David R;
... Wilkinson, Robert J; + view all
(2024)
Advancing the chemotherapy of tuberculous meningitis: a consensus view.
The Lancet Infectious Diseases
10.1016/s1473-3099(24)00512-7.
(In press).
Preview |
Text
Gibb_Gibb_TBM trials revised text unmarked.pdf Download (399kB) | Preview |
Abstract
Summary: Tuberculous meningitis causes death or disability in approximately 50% of affected individuals and kills approximately 78 200 adults every year. Antimicrobial treatment is based on regimens used for pulmonary tuberculosis, which overlooks important differences between lung and brain drug distributions. Tuberculous meningitis has a profound inflammatory component, yet only adjunctive corticosteroids have shown clear benefit. There is an active pipeline of new antitubercular drugs, and the advent of biological agents targeted at specific inflammatory pathways promises a new era of improved tuberculous meningitis treatment and outcomes. Yet, to date, tuberculous meningitis trials have been small, underpowered, heterogeneous, poorly generalisable, and have had little effect on policy and practice. Progress is slow, and a new approach is required. In this Personal View, a global consortium of tuberculous meningitis researchers articulate a coordinated, definitive way ahead via globally conducted clinical trials of novel drugs and regimens to advance treatment and improve outcomes for this life-threatening infection.
| Type: | Article |
|---|---|
| Title: | Advancing the chemotherapy of tuberculous meningitis: a consensus view |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/s1473-3099(24)00512-7 |
| Publisher version: | http://dx.doi.org/10.1016/s1473-3099(24)00512-7 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10198100 |
Archive Staff Only
 |
View Item |
