Desai, T;
Roberts, M;
Bottoms, L;
(2021)
Effects of short-term continuous Montmorency tart cherry juice supplementation in participants with metabolic syndrome.
European Journal of Nutrition
, 60
(3)
pp. 1587-1603.
10.1007/s00394-020-02355-5.
Preview |
Text
Desai_Amended Draft 3 Manuscript EJN.pdf Download (684kB) | Preview |
Abstract
Purpose: Metabolic Syndrome (MetS) augments the incidence of cardiovascular disease by two-fold and type II diabetes mellitus by five-fold. Montmorency tart cherries are rich in phytochemicals shown to improve biomarkers related to cardio-metabolic health in humans. This study aimed to examine cardio-metabolic responses after 7-days Montmorency tart cherry juice (MTCJ) supplementation and also acute on short-term supplementation responses to a single bolus, in humans with MetS. Methods: In a randomised, single-blind, placebo-controlled, crossover trial, 12 participants with MetS (50 ± 10 years; 6M/6F), consumed MTCJ or placebo (PLA) for 7 days. Blood-based and functional cardio-metabolic biomarkers were measured pre- and post-supplementation, and acute responses measured pre-bolus and up to 5 h post-bolus on the 7th day. Results: 24-h ambulatory systolic (P = 0.016), diastolic (P = 0.009) blood pressure and mean arterial pressure (P = 0.041) were significantly lower after 7-days MTCJ supplementation compared to PLA. Glucose (P = 0.038), total cholesterol (P = 0.036), LDL (P = 0.023) concentrations, total cholesterol:HDL ratio (P = 0.004) and respiratory exchange ratio values (P = 0.009) were significantly lower after 6-days MTCJ consumption compared to PLA. Conclusions: This study revealed for the first time in humans that MTCJ significantly improved 24-h BP, fasting glucose, total cholesterol and total cholesterol:HDL ratio, and also lowered resting respiratory exchange ratio compared to a control group. Responses demonstrated clinically relevant improvements on aspects of cardio-metabolic function, emphasising the potential efficacy of MTCJ in preventing further cardio-metabolic dysregulation in participants with MetS. Registered at clinicaltrials.gov (NCT03619941).
| Type: | Article |
|---|---|
| Title: | Effects of short-term continuous Montmorency tart cherry juice supplementation in participants with metabolic syndrome |
| Location: | Germany |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/s00394-020-02355-5 |
| Publisher version: | http://dx.doi.org/10.1007/s00394-020-02355-5 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Nutrition & Dietetics, Ambulatory blood pressure, Anthocyanins, Cardio-metabolic health, Diabetes, Functional foods, Hypertension, BLOOD-PRESSURE, PRUNUS-CERASUS, ARTERIAL STIFFNESS, VASCULAR FUNCTION, CONSUMPTION, INFLAMMATION, REDUCTION, MARKERS, ADULTS, MEN |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10199614 |
Archive Staff Only
 |
View Item |
