Spiro, Simon;
Pereira, Marta;
Bates, Kieran A;
Jaunmuktane, Zane;
Everest, David J;
Stidworthy, Mark F;
Denk, Daniela;
... Fiddaman, Steven; + view all
(2024)
Incidence and characterization of polyglucosan bodies in the cerebella of montserrat orioles (Icterus oberi).
Veterinary Pathology
10.1177/03009858241270000.
(In press).
Preview |
Text
Lawson_Simon Spiro.pdf Download (276kB) | Preview |
Abstract
Polyglucosan bodies are accumulations of insoluble glucose polymers and proteins that form intracytoplasmic inclusions in the brain, large numbers of which can be indicative of neurodegenerative diseases such as Lafora disease. Montserrat orioles (Icterus oberi) are an icterid passerine endemic to Montserrat with conservation populations maintained in captivity abroad. We demonstrate that polyglucosan bodies are unusually abundant in the cerebellar molecular and Purkinje cell layers and cerebellar peduncles of captive-bred and wild-caught Montserrat orioles. The bodies are periodic acid-Schiff positive and diastase resistant and label with concanavalin A and for ubiquitin, consistent with those seen in humans. We found no association of the polyglucosan bodies with concurrent neurological lesions or clinical signs, nor with EPM2A and EPM2B gene mutations associated with Lafora disease. We conclude that an abundance of cerebellar polyglucosan bodies may be a normal finding in aged Montserrat orioles and not a threat to the captive breeding population.
| Type: | Article |
|---|---|
| Title: | Incidence and characterization of polyglucosan bodies in the cerebella of montserrat orioles (Icterus oberi) |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1177/03009858241270000 |
| Publisher version: | https://doi.org/10.1177/03009858241270000 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | corpora amylacea, Icterus oberi, Lafora disease, Montserrat oriole, polyglucosan body |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10199976 |
Archive Staff Only
 |
View Item |
