Kim, Mina;
Naish, Josephine;
Tibiletti, Marta;
Needleman, Sarah;
Szmul, Adam;
Higgins, David;
O’Connor, James;
(2022)
Oxygen-enhanced MRI of the lung at 3 tesla: R2* contrast in smokers and non-smokers.
Presented at: Joint Annual Meeting ISMRM-ESMRMB ISMRT 31st Annual Meeting, London, UK.
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Abstract
T1-weighted dynamic lung OE-MRI is challenging at 3 T using gradient echo acquisitions due to decreased T1 relaxivity of oxygen and substantial ∆R2* contribution. We implemented a dual echo T1-FFE-based method at 3 T and evaluated signal enhancement behaviour and ∆R2*. The proposed method is shown to produce negative contrast on oxygen enhancement signal due to dominance of ∆R2* at TE larger than 0.4 ms. We also demonstrated that the contrast property of the percentage signal enhancement (PSE) is TE dependent. Longer TE enables differentiation on PSE values between non-smokers and smokers.
| Type: | Conference item (Presentation) |
|---|---|
| Title: | Oxygen-enhanced MRI of the lung at 3 tesla: R2* contrast in smokers and non-smokers |
| Event: | Joint Annual Meeting ISMRM-ESMRMB ISMRT 31st Annual Meeting |
| Location: | London, UK |
| Dates: | 7 May 2022 - 12 May 2022 |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.58530/2022/1481 |
| Publisher version: | http://dx.doi.org/10.58530/2022/1481 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10200597 |
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