Doherty, Adam;
Buchanan, Ian;
Roche i Morgó, Oriol;
Astolfo, Alberto;
Savvidis, Savvas;
Gerli, Mattia FM;
Citro, Antonio;
... Endrizzi, Marco; + view all
(2024)
Hybrid dark-field and attenuation contrast retrieval for laboratory-based X-ray tomography.
Optica
, 11
(12)
p. 1603.
10.1364/optica.525760.
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Abstract
X-ray dark-field imaging highlights sample structures through contrast generated by sub-resolution features within the inspected volume. Quantifying dark-field signals generally involves multiple exposures for phase retrieval, separating contributions from scattering, refraction, and attenuation. Here, we introduce an approach for non-interferometric X-ray dark-field imaging that presents a single-parameter representation of the sample. This fuses attenuation and dark-field signals, enabling the reconstruction of a unified three-dimensional volume. Notably, our method can obtain dark-field contrast from a single exposure and employs conventional back projection algorithms for reconstruction. Our approach is based on the assumption of a macroscopically homogeneous material, which we validate through experiments on phantoms and on biological tissue samples. The methodology is implemented on a laboratory-based, rotating anode X-ray tube system without the need for coherent radiation or a high-resolution detector. Utilizing this system with streamlined data acquisition enables expedited scanning while maximizing dose efficiency. These attributes are crucial in time- and dose-sensitive medical imaging applications and unlock the ability of dark-field contrast with high-throughput lab-based tomography. We believe that the proposed approach can be extended across X-ray dark-field imaging implementations beyond tomography, spanning fast radiography, directional dark-field imaging, and compatibility with pulsed X-ray sources.
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