Canu, Giovanni;
Correra, Rosa maria;
Díez Pinel, Guillermo;
Castellan, Raphael;
Denti, Laura;
Fantin, Alessandro;
Ruhrberg, Christiana;
(2024)
A Pax3 lineage gives rise to transient haematopoietic progenitors.
Development
, 151
(23)
, Article dev202924. 10.1242/dev.202924.
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Abstract
During embryonic development, muscle tissues, skin, and a subset of vascular endothelial cells arise from Pax3-expressing embryonic progenitors defined as paraxial mesoderm. By contrast, haemogenic potential is well established for extra-embryonic mesoderm and intra-embryonic lateral plate mesoderm, which do not express Pax3. To date, it is not known whether the haematopoietic system also contains Pax3 lineage cells. Here, we show that the mouse foetal liver and foetal circulation contain a transient population of Pax3 lineage cells with hallmarks of haematopoietic progenitors and the potential to generate both myeloid and erythroid cells. We propose that Pax3 lineage haematopoietic cells should be investigated to better understand normal haematopoietic development from different mesodermal derivatives. Further, genetic alterations of Pax3 lineage haematopoietic cells should be investigated for their potential to cause haematopoietic malignancies
| Type: | Article |
|---|---|
| Title: | A Pax3 lineage gives rise to transient haematopoietic progenitors |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1242/dev.202924 |
| Publisher version: | https://doi.org/10.1242/dev.202924 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons License. The images or other third-party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Pax3, Foetal liver, Hematopoietic development, Macrophage origin, Paraxial mesoderm, Vascular endothelial cell, Mouse |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10201095 |
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