Bullock, M Elise;
Hogan, Thea;
Williams, Cayman;
Morris, Sinead;
Nowicka, Maria;
Sharjeel, Minahil;
van Dorp, Christiaan;
... Seddon, Benedict; + view all
(2024)
The dynamics and longevity of circulating CD4+ memory T cells depend on cell age and not the chronological age of the host.
PLoS Biology
, 22
(8)
, Article e3002380. 10.1371/journal.pbio.3002380.
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Abstract
Quantifying the kinetics with which memory T cell populations are generated and maintained is essential for identifying the determinants of the duration of immunity. The quality and persistence of circulating CD4 effector memory (TEM) and central memory (TCM) T cells in mice appear to shift with age, but it is unclear whether these changes are driven by the aging host environment, by cell age effects, or both. Here, we address these issues by combining DNA labelling methods, established fate-mapping systems, a novel reporter mouse strain, and mathematical models. Together, these allow us to quantify the dynamics of both young and established circulating memory CD4 T cell subsets, within both young and old mice. We show that that these cells and their descendents become more persistent the longer they reside within the TCM and TEM pools. This behaviour may limit memory CD4 T cell diversity by skewing TCR repertoires towards clones generated early in life, but may also compensate for functional defects in new memory cells generated in old age.
| Type: | Article |
|---|---|
| Title: | The dynamics and longevity of circulating CD4+ memory T cells depend on cell age and not the chronological age of the host |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1371/journal.pbio.3002380 |
| Publisher version: | http://dx.doi.org/10.1371/journal.pbio.3002380 |
| Language: | English |
| Additional information: | © 2024 Bullock et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10201125 |
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