Dauncey, Elizabeth M;
Sheppard, Tom D;
Smith, Peter D;
Munday, Rachel H;
(2024)
Remote Alkynylation of Aliphatic Amines.
Organic Letters
10.1021/acs.orglett.4c03468.
(In press).
![]() |
Text
Accepted Manuscript 2024-11-18.pdf - Accepted Version Access restricted to UCL open access staff until 28 November 2025. Download (709kB) |
Abstract
Advancements in transition metal catalyzed C-H activation/functionalization cascades have allowed the synthetic chemist's toolbox to be significantly expanded. Despite this, protocols for the remote alkynylation of linear aliphatic amines still remain limited. Herein, a palladium-catalyzed directing-group approach to alkynylation of aliphatic amines is disclosed. The synthetic utility was demonstrated with a gram-scale reaction and a functional group compatibility test.
Type: | Article |
---|---|
Title: | Remote Alkynylation of Aliphatic Amines |
Location: | United States |
DOI: | 10.1021/acs.orglett.4c03468 |
Publisher version: | http://dx.doi.org/10.1021/acs.orglett.4c03468 |
Language: | English |
Additional information: | Saved FT to S: drive, checked copyright (applied 12-month embargo), improved metadata, made live (DK 11/12/2024). |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry |
URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10201327 |
Archive Staff Only
![]() |
View Item |