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Remote Alkynylation of Aliphatic Amines

Dauncey, Elizabeth M; Sheppard, Tom D; Smith, Peter D; Munday, Rachel H; (2024) Remote Alkynylation of Aliphatic Amines. Organic Letters 10.1021/acs.orglett.4c03468. (In press).

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Abstract

Advancements in transition metal catalyzed C-H activation/functionalization cascades have allowed the synthetic chemist's toolbox to be significantly expanded. Despite this, protocols for the remote alkynylation of linear aliphatic amines still remain limited. Herein, a palladium-catalyzed directing-group approach to alkynylation of aliphatic amines is disclosed. The synthetic utility was demonstrated with a gram-scale reaction and a functional group compatibility test.

Type: Article
Title: Remote Alkynylation of Aliphatic Amines
Location: United States
DOI: 10.1021/acs.orglett.4c03468
Publisher version: http://dx.doi.org/10.1021/acs.orglett.4c03468
Language: English
Additional information: Saved FT to S: drive, checked copyright (applied 12-month embargo), improved metadata, made live (DK 11/12/2024).
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry
URI: https://discovery-pp.ucl.ac.uk/id/eprint/10201327
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