Motl, Robert W;
Sandroff, Brian M;
Hernandez, Roberto S;
Amato, Maria Pia;
Brichetto, Giampaolo;
Chataway, Jeremy;
Chiaravalloti, Nancy D;
... CogEx Research Team; + view all
(2024)
Heterogeneity of aerobic fitness changes with exercise training in progressive multiple sclerosis: Secondary, exploratory analysis of data from the CogEx trial.
Multiple Sclerosis Journal - Experimental, Translational and Clinical
, 10
(4)
10.1177/20552173241301030.
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Abstract
BACKGROUND: There is heterogeneity of aerobic fitness (VO2peak) changes with a standardized exercise training stimulus in the general population (i.e. some participants demonstrate improvements, others no change, and some a reduction in VO2peak). OBJECTIVES: This secondary, exploratory analysis of data examined the heterogeneity of VO2peak responses and possible correlates among persons with progressive multiple sclerosis (PMS) from the CogEx trial. METHODS: CogEx was a multi-site, multi-arm, randomized, double-blinded, and sham-controlled trial undertaken by 11 sites in six different countries. Participants were randomized into one of four conditions with different combinations of exercise training and cognitive rehabilitation including respective sham conditions. The analysis focuses primarily on VO2peak change for the pooled exercise training intervention conditions compared with the pooled sham exercise control conditions. RESULTS: Waterfall plots for change in VO2peak suggested greater heterogeneity with exercise training than sham, and the proportions of difference in VO2peak change (i.e. improvement/worsening) were significantly different between exercise training and sham conditions(p < 0.05). The multivariable analysis indicated that lower baseline VO2peak (p < 0.001) was the only statistically significant correlate of increases in VO2peak with exercise training. CONCLUSION: Our results highlight the heterogeneity of change in VO2peak with exercise training that is correlated with initial aerobic capacity in PMS, and such results may inform hypothesis testing in future clinical trials of exercise training.
| Type: | Article |
|---|---|
| Title: | Heterogeneity of aerobic fitness changes with exercise training in progressive multiple sclerosis: Secondary, exploratory analysis of data from the CogEx trial |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1177/20552173241301030 |
| Publisher version: | https://doi.org/10.1177/20552173241301030 |
| Language: | English |
| Additional information: | Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
| Keywords: | Exercise, heterogeneity, progressive MS |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10201502 |
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