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Eph signaling is required for segmentation and differentiation of the somites

Durbin, Lindsey; Brennan, Caroline; Shiomi, Kensuke; Cooke, Julie; Barrios, Arantza; Shanmugalingam, Shantha; Guthrie, Brenda; ... Holder, Nigel; + view all (1998) Eph signaling is required for segmentation and differentiation of the somites. Genes and Development , 12 (19) pp. 3096-3109. 10.1101/gad.12.19.3096. Green open access

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Abstract

Somitogenesis involves the segmentation of the paraxial mesoderm into units along the anteroposterior axis. Here we show a role for Eph and ephrin signaling in the patterning of presomitic mesoderm and formation of the somites. Ephrin-A-L1 and ephrin-B2 are expressed in an iterative manner in the developing somites and presomitic mesoderm, as is the Eph receptor EphA4. We have examined the role of these proteins by injection of RNA, encoding dominant negative forms of Eph receptors and ephrins. Interruption of Eph signaling leads to abnormal somite boundary formation and reduced or disturbed myoD expression in the myotome. Disruption of Eph family signaling delays the normal down-regulation of her1 and Delta D expression in the anterior presomitic mesoderm and disrupts myogenic differentiation. We suggest that Eph signaling has a key role in the translation of the patterning of presomitic mesoderm into somites.

Type: Article
Title: Eph signaling is required for segmentation and differentiation of the somites
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1101/gad.12.19.3096
Publisher version: https://doi.org/10.1101/gad.12.19.3096
Language: English
Additional information: This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Somitogenesis; Eph/ephrin signaling; zebrafish
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: https://discovery-pp.ucl.ac.uk/id/eprint/10201551
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