Vaughan, Megan;
Tay, Nicole;
Kalitzeos, Angelos;
Kane, Thomas;
Singh, Nav;
Zheng, Adrian;
Dixit, Mira;
... Patterson, Emily J; + view all
(2024)
Changes in Waveguiding Cone Photoreceptors and Color Vision in Patients With Diabetes Mellitus.
Investigative Ophthalmology & Visual Science (IOVS)
, 65
(14)
p. 28.
10.1167/iovs.65.14.28.
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Abstract
PURPOSE: Although it is well known that photoreceptor damage and color vision loss occur in patients with diabetic retinopathy (DR), the relationship between structural and functional changes in diabetes mellitus (DM) remains unclear. Using highly sensitive measures of photoreceptor structure and function, we aim to determine whether early loss of color sensitivity in DM is also accompanied by decreased cone density. METHODS: Monocular data from 26 patients with DM and 25 healthy controls were examined to assess cone photoreceptor metrics, using confocal adaptive optics scanning light ophthalmoscopy, and red/green (RG) and yellow/blue (YB) color vision thresholds, using the Colour Assessment and Diagnosis test. RESULTS: Both RG and YB thresholds were significantly greater in patients with DM than in the healthy controls (RG and YB = P < 0.001), and there were statistically significant differences between the 2 groups in confocal cone density at 1 degree (P = 0.024), and intercell regularity at both 1 (P = 0.013) and 2 degrees (P = 0.012). In patients with DM, cone density was inversely correlated with YB (at 0.5, 1 and 2 degrees, all P values < 0.041), but not for RG color vision thresholds. CONCLUSIONS: This is the first study to investigate the relationship between cone metrics and color vision in patients with DM. The results reveal a significant inverse relationship between confocal cone density and color vision thresholds at the locations assessed within the foveal region. These findings represent a significant advancement in oculomics research.
| Type: | Article |
|---|---|
| Title: | Changes in Waveguiding Cone Photoreceptors and Color Vision in Patients With Diabetes Mellitus |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1167/iovs.65.14.28 |
| Publisher version: | https://doi.org/10.1167/iovs.65.14.28 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. |
| Keywords: | Humans, Color Vision Defects, Diabetic Retinopathy, Ophthalmoscopy, Color Perception Tests, Cell Count, Color Perception, Adult, Aged, Middle Aged, Female, Male, Retinal Cone Photoreceptor Cells, Color Vision |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > UCL Medical School |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10202546 |
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