Spinou, Marianna;
Naska, Androniki;
Nelson, Christopher P;
Codd, Veryan;
Samani, Nilesh J;
Bountziouka, Vasiliki;
(2024)
Micronutrient intake and telomere length: findings from the UK Biobank.
European Journal of Nutrition
, 63
(8)
pp. 2871-2883.
10.1007/s00394-024-03460-5.
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Abstract
Purpose: To investigate whether micronutrient intake from food as well as the regular uptake of specific vitamins and/or minerals are associated with leucocyte telomere length (LTL). Methods: This is a cross-sectional study using data from 422,693 UK Biobank participants aged from 40 to 69 years old, during 2006–2010. LTL was measured as the ratio of telomere repeat number to a single–copy gene and was loge-transformed and z-standardized (z-LTL). Information concerning supplement use was collected at baseline through the touchscreen assessment, while micronutrient intake from food were self-reported through multiple web-based 24 h recall diaries. The association between micronutrient intake or supplement use and z-LTL was assessed using multivariable linear regression models adjusting for demographic, lifestyle and clinical characteristics. Results: About 50% (n = 131,810) of the participants, with complete data on all covariates, self-reported regular supplement intake. Whilst overall supplement intake was not associated with z-LTL, trends toward shorter z-LTL with regular vitamin B (-0.019 (95% CI: -0.041; 0.002)) and vitamin B9 (-0.027 (-0.054; 0.000)) supplement intake were observed. z-LTL was associated with food intake of pantothenic acid (-0.020 (-0.033; -0.007)), vitamin B6 (-0.015 (-0.027; -0.003)), biotin (0.010 (0.002; 0.018)) and folate (0.016 (0.003; 0.030)). Associations of z-LTL with these micronutrients were differentiated according to supplement intake. Conclusion: Negative associations equivalent to a year or less of age-related change in LTL between micronutrient intake and LTL were observed. Due to this small effect, the clinical importance of the associations and any relevance to the effects of vitamin and micronutrient intake toward chronic disease prevention remains uncertain.
| Type: | Article |
|---|---|
| Title: | Micronutrient intake and telomere length: findings from the UK Biobank |
| Location: | Germany |
| DOI: | 10.1007/s00394-024-03460-5 |
| Publisher version: | https://doi.org/10.1007/s00394-024-03460-5 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Nutrition & Dietetics, Leukocyte telomere length, Micronutrients, Supplements, Vitamins, Minerals, CIGARETTE-SMOKING, PHYSICAL-ACTIVITY, OXFORD WEBQ, LIFE-STYLE, ASSOCIATIONS, CONSUMPTION, DIET, FOOD, ATHEROSCLEROSIS, PARTICIPANTS |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Population, Policy and Practice Dept |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10202970 |
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