Brunet, J; Walsh, CL; Tafforeau, P; Dejea, H; Cook, AC; Bellier, A; Engel, K; ... Lee, PD; + view all Brunet, J; Walsh, CL; Tafforeau, P; Dejea, H; Cook, AC; Bellier, A; Engel, K; Jonigk, DD; Ackermann, M; Lee, PD; - view fewer (2024) Hierarchical phase-contrast tomography: a non-destructive multiscale imaging approach for whole human organs. In: Müller, Bert and Wang, Ge, (eds.) Proceedings of SPIE - The International Society for Optical Engineering. (pp. pp. 1-6). Society of Photo-Optical Instrumentation Engineers (SPIE)

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Abstract

Achieving cellular-resolution imaging of intact human organs is critical for improving our understanding of anatomy and pathology. Traditional clinical imaging and histological methods often fail to provide both global and detailed views of entire organs. Hierarchical Phase-Contrast Tomography (HiP-CT), an approach leveraging the ESRF’s Extremely Brilliant Source upgrade to perform non-destructive, high-resolution imaging of intact human organs addresses these limitations. HiP-CT allows for whole organ scans at <20 μm/voxel, with localized zooms down to 2 μm/voxel, bridging the gap between clinical imaging and histology. This multi-scale capability enables detailed examination of anatomical structures and pathologies. We provide here the last developments of HiP-CT, along with various applications on human organs. HiP-CT has shown potential in research areas such as COVID-19 affected lungs and cardiac studies. Despite challenges like high radiation doses and data management, HiP-CT represents a significant advancement in biomedical imaging, with future research aiming to extend its application, correlative imaging upscale and downscale, and enhance data accessibility.

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