Martí-Juan, Gerard;
Sastre-Garriga, Jaume;
Vidal-Jordana, Angela;
Llufriu, Sara;
Martinez-Heras, Eloy;
Groppa, Sergiu;
González-Escamilla, Gabriel;
... Pareto, Deborah; + view all
(2024)
Conservation of structural brain connectivity in people with multiple sclerosis.
Network Neuroscience
, 8
(4)
pp. 1545-1562.
10.1162/netn_a_00404.
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Abstract
Multiple sclerosis (MS) is a neurodegenerative disease that affects the central nervous system. Structures affected in MS include the corpus callosum, connecting the hemispheres. Studies have shown that in mammalian brains, structural connectivity is organized according to a conservation principle, an inverse relationship between intra- and interhemispheric connectivity. The aim of this study was to replicate this conservation principle in subjects with MS and to explore how the disease interacts with it. A multicentric dataset has been analyzed including 513 people with MS and 208 healthy controls from seven different centers. Structural connectivity was quantified through various connectivity measures, and graph analysis was used to study the behavior of intra- and interhemispheric connectivity. The association between the intra- and the interhemispheric connectivity showed a similar strength for healthy controls (r = 0.38, p < 0.001) and people with MS (r = 0.35, p < 0.001). Intrahemispheric connectivity was associated with white matter fraction (r = 0.48, p < 0.0001), lesion volume (r = -0.44, p < 0.0001), and the Symbol Digit Modalities Test (r = 0.25, p < 0.0001). Results show that this conservation principle seems to hold for people with MS. These findings support the hypothesis that interhemispheric connectivity decreases at higher cognitive decline and disability levels, while intrahemispheric connectivity increases to maintain the balance.
| Type: | Article |
|---|---|
| Title: | Conservation of structural brain connectivity in people with multiple sclerosis |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1162/netn_a_00404 |
| Publisher version: | https://doi.org/10.1162/netn_a_00404 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons License. The images or other third-party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Hemispheric connectivity, MRI, Multiple sclerosis, Structural connectivity |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neuroinflammation |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10203106 |
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