Zinab, Beakal;
Ali, Rahma;
Megersa, Bikila S;
Belachew, Tefera;
Kedir, Elias;
Girma, Tsinuel;
Admasu, Bitiya;
... Yilma, Daniel; + view all
(2024)
Associations of body composition at birth and accretion from 0-5 years with kidney function and volume at the 10-year follow-up: the Ethiopian iABC birth cohort.
The American Journal of Clinical Nutrition
10.1016/j.ajcnut.2024.12.015.
(In press).
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Abstract
Background: Fat mass (FM) and fat-free mass (FFM) in early life are associated with later obesity and cardio-metabolic disease. This study aimed to assess the associations of FM and FFM at birth and conditional FM and FFM accretion from 0-5 years with kidney outcomes at the 10-year follow-up.// Method: The Ethiopian Infant Anthropometry and Body Composition (iABC) birth cohort included term infants born in Jimma town, with a birth weight ≥1500 grams, and having no congenital malformations. Air displacement plethysmography was used to measure body composition. Serum cystatin C was determined and kidney dimensions assessed by ultrasound when children were aged ∼10 years. Conditional growth modelling was used to compute FM and FFM accretion between different time points over 0-5 years. Multiple linear regression analysis was used to examine associations of birth FM and FFM and conditional FM and FFM accretion in selected age periods with serum cystatin C and total kidney volume at the 10-year follow-up.// Result: A total of 350 children were followed-up at a mean age of 9.8 9.8 (±1.0) years. A 1 SD higher conditional FFM accretion from 3-6 months was associated with 7.6% (95% CI: 1.9; 13.0) lower serum cystatin C but higher conditional FFM accretion 48-60 months was associated with 5.3% (95% CI: 1.9; 9.0) higher serum cystatin C. A 1 SD higher conditional FM accretion in the periods 6 months-48 months and 48-60 months was associated with β=7.7 (95% CI: 4.8; 10.7) and β=6.4 (95% CI: 1.6; 11.1) cm³ greater kidney volume, respectively. A 1 SD higher birth FFM and FFM accretion in the periods 3-6 months, 6 months-48 months and 48-60 months was associated with β=4.7 (95% CI: 2.1, 7.2), 14.1 (95% CI: 6.3; 22.0), 4.2 (95% CI: 0.9; 7.4) and 7.1 (95% CI: 2.5; 11.7) cm³ greater kidney volume, respectively.// Conclusion: A higher conditional FFM gain in age from 3-6 months resulted in better kidney function at the 10-year follow-up, whilst a higher conditional FFM gain in age from 4-5 years resulted a lower kidney function. Kidney volume at the 10-year follow-up was associated with higher birth FFM and higher conditional FM or FFM growth in most growth periods.
| Type: | Article |
|---|---|
| Title: | Associations of body composition at birth and accretion from 0-5 years with kidney function and volume at the 10-year follow-up: the Ethiopian iABC birth cohort |
| Location: | United States |
| DOI: | 10.1016/j.ajcnut.2024.12.015 |
| Publisher version: | https://doi.org/10.1016/j.ajcnut.2024.12.015 |
| Language: | English |
| Additional information: | This version is the author-accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Ethiopia, Fat mass, Kidney size, fat-free mass, kidney function |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Population, Policy and Practice Dept |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10203178 |
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