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Analysis of Multidimensional Clinical and Physiological Data with Synolitical Graph Neural Networks

Krivonosov, Mikhail; Nazarenko, Tatiana; Ushakov, Vadim; Vlasenko, Daniil; Zakharov, Denis; Chen, Shangbin; Blyus, Oleg; (2024) Analysis of Multidimensional Clinical and Physiological Data with Synolitical Graph Neural Networks. Technologies , 13 (1) , Article 13. 10.3390/technologies13010013. Green open access

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Abstract

This paper introduces a novel approach for classifying multidimensional physiological and clinical data using Synolitic Graph Neural Networks (SGNNs). SGNNs are particularly good for addressing the challenges posed by high-dimensional datasets, particularly in healthcare, where traditional machine learning and Artificial Intelligence methods often struggle to find global optima due to the “curse of dimensionality”. To apply Geometric Deep Learning we propose a synolitic or ensemble graph representation of the data, a universal method that transforms any multidimensional dataset into a network, utilising only class labels from training data. The paper demonstrates the effectiveness of this approach through two classification tasks: synthetic and fMRI data from cognitive tasks. Convolutional Graph Neural Network architecture is then applied, and the results are compared with established machine learning algorithms. The findings highlight the robustness and interpretability of SGNNs in solving complex, high-dimensional classification problems.

Type: Article
Title: Analysis of Multidimensional Clinical and Physiological Data with Synolitical Graph Neural Networks
Open access status: An open access version is available from UCL Discovery
DOI: 10.3390/technologies13010013
Publisher version: https://doi.org/10.3390/technologies13010013
Language: English
Additional information: © 2024 by the Authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Keywords: networks; data analysis; graph neural networks
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Womens Cancer
URI: https://discovery-pp.ucl.ac.uk/id/eprint/10203441
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