Irwandi, Rizky Aditya;
Marruganti, Crystal;
Collins, George;
Carvalho, Jhonatan de Souza;
Gilroy, Derek;
D'Aiuto, Francesco;
(2024)
The translational potential of inflammation-induced skin blister human models in exploring the pathogenesis of periodontitis and its systemic health implications.
Frontiers in Immunology
, 15
, Article 1469828. 10.3389/fimmu.2024.1469828.
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Abstract
Periodontitis is a highly prevalent chronic disease. Despite decades of extensive research on the topic, a complete understanding of its immunopathogenesis, especially when linked to other inflammatory comorbidities, is lacking. Ex vivo human and in vivo animal experiments have shown the host inflammatory response’s crucial role in both the disease’s onset and its systemic implications. These approaches, however, remain questionable when translating these findings into real-world scenarios linked to periodontitis. A clear need for new in vivo human models is discussed, especially within the context of understanding the host response to key pathogens linked to periodontitis, such as Porphyromonas gingivalis (P. gingivalis). Therefore, a skin blister model was employed to describe the stages of the host immune response in humans after challenges by microbial and/or sterile insults. A novel human challenge model using UV-killed P. gingivalis holds promise in producing new evidence and bridging the gap of the host response to periodontitis and its links with other common chronic diseases.
| Type: | Article |
|---|---|
| Title: | The translational potential of inflammation-induced skin blister human models in exploring the pathogenesis of periodontitis and its systemic health implications |
| Location: | Switzerland |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fimmu.2024.1469828 |
| Publisher version: | https://doi.org/10.3389/fimmu.2024.1469828 |
| Language: | English |
| Additional information: | Copyright © 2024 Irwandi, Marruganti, Collins, Carvalho, Gilroy and D’Aiuto. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Immunology, human challenge model, periodontitis, <italic>Porphyromonas gingivalis</italic>, skin blister model, periodontal disease, self-resolving inflammation, periodontitis pathogenesis, periodontitis-systemic link, GENOME-WIDE ASSOCIATION, PRO-RESOLVING MEDIATORS, TUMOR-NECROSIS-FACTOR, T-CELL ACCUMULATION, ALVEOLAR BONE LOSS, PORPHYROMONAS-GINGIVALIS, HOST-RESPONSE, PERIPHERAL-BLOOD, INTERFERON-GAMMA, CHALLENGE |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Restorative Dental Sciences |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10204130 |
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