Jalil, Banaz;
Rollinger, Judith M;
Atanasov, Atanas G;
Singla, Rajeev K;
Kinghorn, A Douglas;
Heinrich, Michael;
(2024)
Core publications in drug discovery and natural product research.
Frontiers in Natural Products
, 3
, Article 1493720. 10.3389/fntpr.2024.1493720.
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Abstract
Natural products have long been a cornerstone of drug discovery, providing diverse and biologically relevant chemical scaffolds. This work aims to guide newcomers to natural product research and, specifically, drug discovery by presenting a curated list of 30 key publications selected through an international survey of experts and critical evaluation by the authors. The selected works span textbooks, review articles, and original research papers, covering various aspects of natural product research, including chemistry, pharmacology, analytical sciences, emerging open science, and computational approaches. We discuss historical milestones in natural product drug discovery, highlighting the specific contributions of the U.S. National Cancer Institute in developing anticancer and anti-HIV agents. The present work also addresses current challenges and innovations in the field, emphasizing the importance of data quality, interdisciplinary collaboration, and the integration of artificial intelligence. By providing this carefully selected reading list and accompanying analysis, we aim to offer a comprehensive yet accessible entry point for researchers new to natural product-based drug discovery and highlight future directions and opportunities in this dynamic field.
| Type: | Article |
|---|---|
| Title: | Core publications in drug discovery and natural product research |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fntpr.2024.1493720 |
| Publisher version: | https://doi.org/10.3389/fntpr.2024.1493720 |
| Language: | English |
| Additional information: | Copyright © 2024 Jalil, Rollinger, Atanasov, Singla, Kinghorn and Heinrich. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY), https://creativecommons.org/licenses/by/4.0/. The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| Keywords: | Natural products, drug discovery, medicinal plants, marine organisms, fungi, microorganisms |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharma and Bio Chemistry |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10204465 |
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