Yiannakouris, N;
Cooper, JA;
Shah, S;
Drenos, F;
Ireland, HA;
Stephens, JW;
Li, KW;
... Humphries, SE; + view all
(2012)
IRS1 gene variants, dysglycaemic metabolic changes and type-2 diabetes risk.
Nutrition, Metabolism and Cardiovascular Diseases
, 22
(12)
1024 - 1030.
10.1016/j.numecd.2011.05.009.
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Abstract
A recent genome-wide association study identified rs2943641C > T, 500 kb from the insulin receptor substrate-1 gene (IRS1), as a type-2 diabetes (T2D) susceptibility locus. We aimed to replicate this association by meta-analysis and examine whether common variants within IRS1, present on the HumanCVD BeadChip, were associated with T2D risk.
| Type: | Article |
|---|---|
| Title: | IRS1 gene variants, dysglycaemic metabolic changes and type-2 diabetes risk. |
| Location: | Netherlands |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.numecd.2011.05.009 |
| Publisher version: | http://dx.doi.org/10.1016/j.numecd.2011.05.009 |
| Language: | English |
| Additional information: | This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. PMCID: PMC3657179 |
| Keywords: | Alleles, Case-Control Studies, Computer Simulation, Diabetes Mellitus, Type 2, Europe, European Continental Ancestry Group, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Glucose Tolerance Test, Homeostasis, Humans, Insulin Receptor Substrate Proteins, Insulin Resistance, Linkage Disequilibrium, Logistic Models, Multivariate Analysis, Odds Ratio, Polymorphism, Single Nucleotide, Prevalence, Promoter Regions, Genetic, Risk Factors |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/1324190 |
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