Cipriani, V;
Matharu, BK;
Khan, JC;
Shahid, H;
Stanton, CM;
Hayward, C;
Wright, AF;
... Yates, JR; + view all
(2012)
Genetic variation in complement regulators and susceptibility to age-related macular degeneration.
Immunobiology
, 217
(2)
158 - 161.
10.1016/j.imbio.2011.09.002.
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Abstract
Age-related macular degeneration (AMD) is the commonest cause of blindness in Western populations. Risk is influenced by age, genetic and environmental factors. Complement activation appears to be important in the pathogenesis and associations have been found between AMD and genetic variations in complement regulators such as complement factor H. We therefore investigated other complement regulators for association with AMD.
| Type: | Article |
|---|---|
| Title: | Genetic variation in complement regulators and susceptibility to age-related macular degeneration. |
| Location: | Netherlands |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.imbio.2011.09.002 |
| Publisher version: | http://dx.doi.org/10.1016/j.imbio.2011.09.002 |
| Language: | English |
| Additional information: | This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. PMCID: PMC3657157 |
| Keywords: | Aged, Aged, 80 and over, Aging, Antigens, CD46, Antigens, CD55, Antigens, CD59, Case-Control Studies, Complement System Proteins, Female, Genetic Association Studies, Genetic Predisposition to Disease, Genetic Variation, Genotype, Humans, Macular Degeneration, Male, Polymorphism, Single Nucleotide, Properdin |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/1329663 |
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