Obara, I;
Géranton, SM;
Hunt, SP;
(2012)
Axonal protein synthesis: a potential target for pain relief?
Current Opinion in Pharmacology
, 12
(1)
42 - 48.
10.1016/j.coph.2011.10.005.
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Abstract
Research on the role of axonal protein synthesis in the regulation of nociceptive mechanisms has grown significantly over the past four years. Recent advances include evidence that local translation of mRNA can occur in adult primary afferents under the control of the mammalian target of rapamycin (mTOR) and the extracellular signal-regulated kinase (ERK) signaling pathways. Studies investigating the effect of mTOR and ERK pathway inhibitors in a number of pain models suggest that these signaling pathways may act independently, depending on the type of sensory afferents studied. The evidence that nociception can be regulated at the level of mRNA translation in nociceptors has important implications for the understanding of the mechanisms of nociceptive plasticity and therefore for therapeutic interventions in chronic pain conditions.
| Type: | Article |
|---|---|
| Title: | Axonal protein synthesis: a potential target for pain relief? |
| Location: | UK |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.coph.2011.10.005 |
| Publisher version: | http://dx.doi.org/10.1016/j.coph.2011.10.005 |
| Language: | English |
| Additional information: | This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| Keywords: | Axons, Extracellular Signal-Regulated MAP Kinases, Gene Expression Regulation, Humans, Nociceptors, Pain |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/1329750 |
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