Kilpeläinen, TO;
Qi, L;
Brage, S;
Sharp, SJ;
Sonestedt, E;
Demerath, E;
Ahmad, T;
... Loos, RJ; + view all
(2011)
Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children.
PLoS Medicine
, 8
(11)
, Article e1001116. 10.1371/journal.pmed.1001116.
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Abstract
The FTO gene harbors the strongest known susceptibility locus for obesity. While many individual studies have suggested that physical activity (PA) may attenuate the effect of FTO on obesity risk, other studies have not been able to confirm this interaction. To confirm or refute unambiguously whether PA attenuates the association of FTO with obesity risk, we meta-analyzed data from 45 studies of adults (n = 218,166) and nine studies of children and adolescents (n = 19,268).
| Type: | Article |
|---|---|
| Title: | Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children. |
| Location: | US |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1371/journal.pmed.1001116 |
| Publisher version: | http://dx.doi.org/10.1371/journal.pmed.1001116 |
| Language: | English |
| Additional information: | © 2011 Loos et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. PMCID: PMC3206047 |
| Keywords: | Adipose Tissue, Adolescent, Adult, Aged, Child, Female, Genetic Predisposition to Disease, Genotype, Humans, Male, Motor Activity, Obesity, Polymorphism, Single Nucleotide, Proteins, Risk Factors |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Population, Policy and Practice Dept |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/1332902 |
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