Hyare, H.; (2010) Quantitative MRI in the diagnosis and monitoring of human prion diseases. Doctoral thesis , UCL (University College London).

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Abstract

This thesis examines the application of cerebral diffusion weighted imaging (DWI) and short echo time (TE) proton magnetic resonance spectroscopy (1H-MRS) for the evaluation of patients with different forms of human prion disease. Human prion diseases are progressive, uniformly fatal neurodegenerative diseases and as treatments are developed, early diagnosis is essential. Particularly important is the diagnosis of presymptomatic cases and prediction of disease onset in these individuals. In this thesis I demonstrate that MRI measures of Apparent Diffusion Coefficient (ADC) at low and high b-value and short TE 1H-MRS are potential neuroimaging biomarkers of prion disease activity. I show that ex-vivo MRI at high field provides important insights into the microstructural changes underlying the sensitivity of some of these quantitative MRI methods to prion disease pathology. The findings presented here exemplify the potential of quantitative MRI in both increasing our understanding of the pathophysiology of prion diseases and in providing neuroimaging biomarkers which will be of great importance for the future evaluation of treatment efficacy.

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