Upile, T;
Elmiyeh, B;
Prasad, V;
Youl, B;
Epstein, R;
Rubin, J;
Jerjes, W;
... Sudhoff, H; + view all
(2009)
Unilateral versus bilateral thyroarytenoid Botulinum toxin injections in adductor spasmodic dysphonia: A prospective study.
Head and Face Medicine
, 5
, Article 20. 10.1186/1746-160X-5-20.
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Abstract
Objectives. In this preliminary prospective study, we compared unilateral and bilateral thyroarytenoid muscle injections of Botulinum toxin (Dysport) in 31 patients with adductor spasmodic dysphonia, who had undergone more than 5 consecutive Dysport injections (either unilateral or bilateral) and had completed 5 concomitant self-rated efficacy and complication scores questionnaires related to the previous injections. We also developed a Neurophysiological Scoring (NPS) system which has utility in the treatment administration. Method and materials. Data were gathered prospectively on voice improvement (self-rated 6 point scale), length of response and duration of complications (breathiness, cough, dysphagia and total voice loss). Injections were performed under electromyography (EMG) guidance. NPS scale was used to describe the EMG response. Dose and unilateral/bilateral injections were determined by clinical judgment based on previous response. Time intervals between injections were patient driven. Results. Low dose unilateral Dysport injection was associated with no significant difference in the patient's outcome in terms of duration of action, voice score (VS) and complication rate when compared to bilateral injections. Unilateral injections were not associated with any post treatment total voice loss unlike the bilateral injections. Conclusion. Unilateral low dose Dysport injections are recommended in the treatment of adductor spasmodic dysphonia.
| Type: | Article |
|---|---|
| Title: | Unilateral versus bilateral thyroarytenoid Botulinum toxin injections in adductor spasmodic dysphonia: A prospective study |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1186/1746-160X-5-20 |
| Publisher version: | http://dx.doi.org/10.1186/1746-160X-5-20 |
| Language: | English |
| Additional information: | © 2009 Upile et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > EDI MaxFac, Diagnostic, Med and Surg Sci |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/1338540 |
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