Taylor, RR;
Jagger, DJ;
Forge, A;
(2012)
Defining the cellular environment in the organ of Corti following extensive hair cell loss: a basis for future sensory cell replacement in the Cochlea.
PLOS One
, 7
(1)
, Article e30577. 10.1371/journal.pone.0030577.
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Abstract
Following the loss of hair cells from the mammalian cochlea, the sensory epithelium repairs to close the lesions but no new hair cells arise and hearing impairment ensues. For any cell replacement strategy to be successful, the cellular environment of the injured tissue has to be able to nurture new hair cells. This study defines characteristics of the auditory sensory epithelium after hair cell loss.
| Type: | Article |
|---|---|
| Title: | Defining the cellular environment in the organ of Corti following extensive hair cell loss: a basis for future sensory cell replacement in the Cochlea. |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1371/journal.pone.0030577 |
| Publisher version: | http://dx.doi.org/10.1371/journal.pone.0030577 |
| Language: | English |
| Additional information: | © 2012 Taylor et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The study was supported by a project grant from the Royal National Institute for Deaf People (RNID). DJJ holds a Royal Society University Research Fellowship. The funders had no role in the study design, data collection and analysis, decision to publish or preparation of the manuscript. |
| Keywords: | Alopecia, Animals, Cell Differentiation, Cellular Microenvironment, Cochlea, Female, Hair Cells, Auditory, Male, Mice, Mice, Inbred C57BL, Mice, Inbred CBA, Organ of Corti, Regeneration, Time Factors, Tissue Therapy |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > The Ear Institute |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/1339437 |
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