Hadjipanayi, E;
Brown, RA;
Mudera, V;
Cheema, U;
(2009)
Engineering angiogenesis by hypoxia-induced signaling: Adopting a physiological approach.
In:
Abstracts of the Tissue and Cell Engineering Society (TCES) meeting 8-10 July 2009, Universities of Glasgow & Strathclyde.
(pp. 15 - 15).
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Abstract
Successful engineering of tissues with clinically relevant size and complexity critically depends on their in vitro pre-vascularization which can promote cell survival, differentiation and rapid vascularization post-implantation. However, mimicking in vitro the physiological complexity of a vascular network currently presents major obstacles1. In this study we tested the hypothesis that a hypoxia-induced signaling (HIS) - cell population can generate the complete angiogenic cascade necessary for inducing endothelial cell sprouting and tubule formation within a 3D construct.
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