Chrzanowski, W; Szade, J; Hart, AD; Armitage, DA; Dalby, MJ; Knowles, JC; (2009) Role of surface nickel content on human cell cytoskeleton formation on Nitinol. In: Abstracts of the Tissue and Cell Engineering Society (TCES) meeting 8-10 July 2009, Universities of Glasgow & Strathclyde. (pp. 54 - 54).

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Abstract

Cell activity on an implant surface can be modulated by cues such as topography, chemistry or stiffness(1,2). For Ni-Ti alloy this is achieved mainly by alteration in chemistry. However, high nickel concentrations may be a concern in the use Nitinol on a larger scale. Current reports on Nitinol bring contradictory data(3-5) suggesting that high nickel content is not particularly dangerous and nickel-titanium alloys are safe to be used. On the other hand it was shown that nickel has a toxic effects on cells(6). Nevertheless, shape memory effects and pseudo-elasticity could support different treatments (e.g. scoliosis) and currently, Nitinol is used to produce porous foams and coatings (Actipore™), pins, clamps and intramedullary nails. In this paper authors investigated a role for nickel surface concentration on influencing cell behaviour e.g. cytoskeleton formation and organization in vitro.

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