Alekseeva, T; Allovskaya, A; Abou Neel, EA; Knowles, JC; Brown, RA; (2008) Development of conical soluble phosphate glass fibres for directional generation of microchannels in dense collagen implants. In: Abstracts of the Tissue and Cell Engineering Society (TCES) meeting 2-4 July 2008, University of Nottingham. (pp. 32 - 32).

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Abstract

Successful integration of the tissue engineered construct depends greatly on the ability of host tissues to innervate and vascularise the implant. To achieve this goal we proposed using dissoluble phosphate-based glass fibres to create microchannels in the plastic compressed collagen gel. To make the ingrowth dynamic we hypothesized that fibres should be conically shaped, so that after implantation the microchannel will open in the direction of increasing diametre. PC collagen is a novel technique for the rapid fabrication of dense collagen bio-mimetic tissues by rapid expulsion of the liquid from hyperhydrated collagen gel.1 Dissolution of phosphate glass (PG) fibres compressed into collagen gels, produce microchannels2 but products from fast dissolving glasses may be detrimental to the seeded cells.3 In this study we tested the viability of Schwann cells (SC) and human bone marrow stromal cells (hBMSC) in the PCC-PGF system and possibility of fabrication of the conically shaped fibres.

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