Wright, KE;
MacRobert, AJ;
Phillips, JB;
(2008)
Assessing the effect of photodynamic therapy on peripheral nerve and cancer cells using a thin tissue engineered collagen culture model.
In:
Abstracts of the Tissue and Cell Engineering Society (TCES) meeting 2-4 July 2008, University of Nottingham.
(pp. 13 - 13).
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Abstract
This study used an innovative thin 3D collagen culture system, to evaluate the response of primary rat peripheral nerve cells to photodynamic therapy (PDT). PDT is a cancer therapy that involves the administration of a photosensitive drug which becomes activated following the focal application of light to tumour sites. The subsequent production of toxic singlet oxygen results in cell death. Clinically, nerve sparing has been observed after meta tetra hydroxyl phenyl chlorine (mTHPC) mediated PDT. This study aims to simulate nerve PDT in culture with a thin tissue engineered collagen scaffold model in order to assess the cellular basis for the phenomenon of peripheral nerve sparing after PDT.
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