Der, G;
Batty, GD;
Benzeval, M;
Deary, IJ;
Green, MJ;
McGlynn, L;
McIntyre, A;
... Shiels, PG; + view all
(2012)
Is telomere length a biomarker for aging: cross-sectional evidence from the west of Scotland?
PLOS One
, 7
(9)
, Article e45166. 10.1371/journal.pone.0045166.
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Abstract
The search for biomarkers of aging (BoAs) has been largely unsuccessful to-date and there is widespread skepticism about the prospects of finding any that satisfy the criteria developed by the American Federation of Aging Research. This may be because the criteria are too strict or because a composite measure might be more appropriate. Telomere length has attracted a great deal of attention as a candidate BoA. We investigate whether it meets the criteria to be considered as a single biomarker of aging, and whether it makes a useful contribution to a composite measure.
| Type: | Article |
|---|---|
| Title: | Is telomere length a biomarker for aging: cross-sectional evidence from the west of Scotland? |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1371/journal.pone.0045166 |
| Publisher version: | http://dx.doi.org/10.1371/journal.pone.0045166 |
| Language: | English |
| Additional information: | © Der et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The West of Scotland Twenty-07 Study is funded by the UK Medical Research Council (MRC) (WBS MC_US_A540_0080) and the data were originally collected by the MRC Social and Public Health Sciences Unit. G. Der, M. Benzeval, M. Green, and T. Robertson are funded by the MRC (WBS MC_US_A540_0080). The University of Edinburgh Centre for Cognitive Ageing and Cognitive Epidemiology is funded as part of the joint UK research council call for Lifelong Health and Wellbeing (G0700704/84698). G. David Batty is a Wellcome Trust Fellow. The funders had no direct role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/1372327 |
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