Morris, SA;
Almeida, AD;
Tanaka, H;
Ohta, K;
Ohnuma, S;
(2007)
Tsukushi modulates Xnr2, FGF and BMP signaling: regulation of Xenopus germ layer formation.
PLOS One
, 2
(10)
, Article e1004. 10.1371/journal.pone.0001004.
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Abstract
Cell-cell communication is essential in tissue patterning. In early amphibian development, mesoderm is formed in the blastula-stage embryo through inductive interactions in which vegetal cells act on overlying equatorial cells. Members of the TGF-beta family such as activin B, Vg1, derrière and Xenopus nodal-related proteins (Xnrs) are candidate mesoderm inducing factors, with further activity to induce endoderm of the vegetal region. TGF-beta-like ligands, including BMP, are also responsible for patterning of germ layers. In addition, FGF signaling is essential for mesoderm formation whereas FGF signal inhibition has been implicated in endoderm induction. Clearly, several signaling pathways are coordinated to produce an appropriate developmental output; although intracellular crosstalk is known to integrate multiple pathways, relatively little is known about extracellular coordination.
| Type: | Article |
|---|---|
| Title: | Tsukushi modulates Xnr2, FGF and BMP signaling: regulation of Xenopus germ layer formation. |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1371/journal.pone.0001004 |
| Publisher version: | http://dx.doi.org/10.1371/journal.pone.0001004 |
| Language: | English |
| Additional information: | © 2007 Morris et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Cancer Research UK, Medical Research Council, FCT Portugal, PRESTO Japan |
| Keywords: | Animals, Bone Morphogenetic Proteins, Cell Communication, Endoderm, Fibroblast Growth Factors, Gene Expression Regulation, Developmental, Germ Cells, Germ Layers, Ligands, Mesoderm, Models, Biological, Signal Transduction, Transforming Growth Factor beta, Xenopus Proteins |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/1372826 |
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