Hubacek, JA;
Piper, BJ;
Pikhart, H;
Peasey, A;
Kubinova, R;
Bobak, M;
(2013)
Lack of an association between left-handedness and APOE polymorphism in a large sample of adults: results of the Czech HAPIEE study.
Laterality
, 18
(5)
513 - 519.
10.1080/1357650X.2012.715164.
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Abstract
An association between APOE genotype and left-handedness has been previously reported. We examined whether such association exists in a population sample of 4438 unrelated Caucasian adults aged 45-69 years (2022 males and 2416 females). Left-handedness was based on self-reported left-hand dominance for writing (prevalence 4.9%) and on consistently higher left-hand grip strength in two repeated measurements (prevalence 12.2%). Individuals with higher left hand grip strength were seven times more likely to be self-reported left handers (p<.0001, χ(2) 159.7, 2 df). There were no differences in the proportion of self-reported left-handedness (p=.828, χ(2) 2.1, 5 df) or higher grip strength in left hand (p=.557, χ(2) 3.9, 5 df) between APOE genotypes. The lack of association was similar in both genders and did not differ by age group. The results suggest that left-handedness in adults is not related to APOE genotype.
| Type: | Article |
|---|---|
| Title: | Lack of an association between left-handedness and APOE polymorphism in a large sample of adults: results of the Czech HAPIEE study. |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1080/1357650X.2012.715164 |
| Publisher version: | http://dx.doi.org/10.1080/1357650X.2012.715164 |
| Language: | English |
| Additional information: | © 2013 The Author(s). Published by Taylor & Francis. This is an Open Access article. Non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly attributed, cited, and is not altered, transformed, or built upon in any way, is permitted. The moral rights of the named author(s) have been asserted. PMCID: PMC3996547 |
| Keywords: | Age Factors, Aged, Apolipoproteins E, Chi-Square Distribution, Czech Republic, Female, Functional Laterality, Genetic Association Studies, Hand Strength, Humans, Male, Middle Aged, Polymorphism, Genetic, Self Report |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/1382138 |
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