Hamurtekin, E;
Fitzsimmons, BL;
Shubayev, VI;
Grafe, MR;
Deumens, R;
Yaksh, TL;
Walker, SM;
(2013)
Evaluation of Spinal Toxicity and Long-term Spinal Reflex Function after Intrathecal Levobupivaciane in the Neonatal Rat.
Anesthesiology
, 119
(1)
142 - 155.
10.1097/ALN.0b013e31828fc7e7.
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Abstract
Neuraxial anesthesia is utilized in children of all ages. Local anesthetics produce dose-dependent toxicity in certain adult models, but the developing spinal cord may also be susceptible to drug-induced apoptosis. In postnatal rodents, we examined the effects of intrathecal levobupivacaine on neuropathology and long-term sensorimotor outcomes.
| Type: | Article |
|---|---|
| Title: | Evaluation of Spinal Toxicity and Long-term Spinal Reflex Function after Intrathecal Levobupivaciane in the Neonatal Rat |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1097/ALN.0b013e31828fc7e7 |
| Publisher version: | http://dx.doi.org/10.1097/ALN.0b013e31828fc7e7 |
| Language: | English |
| Additional information: | Copyright © 2013, the American Society of Anesthesiologists, Inc. Lippincott Williams & Wilkins. |
| Keywords: | Anesthesia, Caudal, Anesthetics, Local, Animals, Animals, Newborn, Apoptosis, Behavior, Animal, Bupivacaine, Calcium-Binding Proteins, Caspase 3, Cauda Equina, Electromyography, Female, Gait, Glial Fibrillary Acidic Protein, Injections, Spinal, Microfilament Proteins, Pain Measurement, Pregnancy, Rats, Rats, Sprague-Dawley, Spinal Cord, Spinal Cord Diseases, Spinal Nerve Roots |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Neurosciences Dept |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/1391668 |
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