Kolluri, KK;
Laurent, GJ;
Janes, SM;
(2013)
Mesenchymal stem cells as vectors for lung cancer therapy.
Respiration
, 85
(6)
443 - 451.
10.1159/000351284.
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Abstract
Despite recent advances in treatment, lung cancer accounts for one third of all cancer-related deaths, underlining the need of development of new therapies. Mesenchymal stem cells (MSCs) possess the ability to specifically home into tumours and their metastases. This property of MSCs could be exploited for the delivery of various anti-tumour agents directly into tumours. However, MSCs are not simple delivery vehicles but cells with active physiological process. This review outlines various agents which can be delivered by MSCs with substantial emphasis on TRAIL (tumour necrosis factor-related apoptosis-inducing ligand).
| Type: | Article |
|---|---|
| Title: | Mesenchymal stem cells as vectors for lung cancer therapy |
| Location: | Switzerland |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1159/000351284 |
| Publisher version: | http://dx.doi.org/10.1159/000351284 |
| Language: | English |
| Additional information: | © 2013 S. Karger AG, Basel. This is an Open Access article licensed under the terms of the Creative Commons Attribution 3.0 Unported license (CC BY 3.0) (www.karger.com/OA-license-WT), applicable to the online version of the article only. |
| Keywords: | Apoptosis, Delivery vectors, Homing, Lung cancer, Mesenchymal stem cells, TRAIL |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Respiratory Medicine |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/1395318 |
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