Paluch, EK;
Raz, E;
(2013)
The role and regulation of blebs in cell migration.
Curr Opin Cell Biol
, 25
(5)
pp. 582-590.
10.1016/j.ceb.2013.05.005.
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Abstract
Blebs are cellular protrusions that have been shown to be instrumental for cell migration in development and disease. Bleb expansion is driven by hydrostatic pressure generated in the cytoplasm by the contractile actomyosin cortex. The mechanisms of bleb formation thus fundamentally differ from the actin polymerization-based mechanisms responsible for lamellipodia expansion. In this review, we summarize recent findings relevant for the mechanics of bleb formation and the underlying molecular pathways. We then review the processes involved in determining the type of protrusion formed by migrating cells, in particular in vivo, in the context of embryonic development. Finally, we discuss how cells utilize blebs for their forward movement in the presence or absence of strong substrate attachment.
| Type: | Article |
|---|---|
| Title: | The role and regulation of blebs in cell migration. |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.ceb.2013.05.005 |
| Publisher version: | http://dx.doi.org/10.1016/j.ceb.2013.05.005 |
| Additional information: | © 2013 Elsevier Ltd. All rights reserved. This work is licensed under a Creative Commons Attribution 3.0 Unported License. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Lab for Molecular Cell Bio MRC-UCL |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/1405719 |
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