Hausenloy, DJ;
Whittington, HJ;
Wynne, AM;
Begum, SS;
Theodorou, L;
Riksen, N;
Mocanu, MM;
(2013)
Dipeptidyl peptidase-4 inhibitors and GLP-1 reduce myocardial infarct size in a glucose-dependent manner.
Cardiovascular Diabetology
, 12
(1)
, Article 154. 10.1186/1475-2840-12-154.
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Abstract
The dipeptidyl peptidase-4 (DPP-4) inhibitors Sitagliptin and Vildagliptin lower blood glucose by augmenting endogenous levels of glucagon-like peptide-1 (GLP-1), an incretin which also confers cardioprotection. As such, we hypothesized that treatment with DPP-4 inhibitors are also cardioprotective.
| Type: | Article |
|---|---|
| Title: | Dipeptidyl peptidase-4 inhibitors and GLP-1 reduce myocardial infarct size in a glucose-dependent manner |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1186/1475-2840-12-154 |
| Publisher version: | http://dx.doi.org/10.1186/1475-2840-12-154 |
| Language: | English |
| Additional information: | © 2013 Hausenloy et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
| Keywords: | Ischaemia, Reperfusion, Glucagon-like peptide 1, Sitagliptin, Vildagliptin, Dipeptidyl peptidase-4 inhibitor, Blood glucose |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Pre-clinical and Fundamental Science |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/1416301 |
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