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T regulatory cells in childhood arthritis - novel insights.

Pesenacker, AM; Wedderburn, LR; (2013) T regulatory cells in childhood arthritis - novel insights. Expert Rev Mol Med , 15 , Article e13. 10.1017/erm.2013.14. Green open access

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Abstract

In recent years, there have been many new developments in the field of regulatory T cells (Treg), challenging the consensus on their behaviour, classification and role(s) in disease. The role Treg might play in autoimmune disease appears to be more complex than previously thought. Here, we discuss the current knowledge of regulatory T cells through animal and human research and illustrate the recent developments in childhood autoimmune arthritis (juvenile idiopathic arthritis (JIA)). Furthermore, this review summarises our understanding of the fields and assesses current and future implications for Treg in the treatment of JIA.

Type: Article
Title: T regulatory cells in childhood arthritis - novel insights.
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1017/erm.2013.14
Publisher version: http://dx.doi.org/10.1017/erm.2013.14
Language: English
Additional information: © Cambridge University Press 2013. The online version of this article is published within an Open Access environment subject to the conditions of the Creative Commons Attribution licence http://creativecommons.org/licenses/by/3.0/.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept
URI: https://discovery-pp.ucl.ac.uk/id/eprint/1420636
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