Zachary, I;
(2014)
Neuropilins: Role in Signalling, Angiogenesis and Disease.
In: Marone, G and Granata, F, (eds.)
Angiogenesis, Lymphangiogenesis and Clinical Implications.
(pp. 37-70).
Karger: Basel, Switzerland.
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Abstract
Neuropilins (NRPs) are co-receptors for class 3 semaphorins and for members of the vascular endothelial growth factor (VEGF) family of angiogenic cytokines. Genetic analysis of the role of NRPs in mice shows that NRP1 is essential for embryonic neuronal pathfinding and cardiovascular development, mediated via semaphorins and VEGF, respectively, while NRP2 has a more restricted role in neuronal patterning and lymphangiogenesis. NRPs are thought to mediate functional responses, most importantly cell migration, as a result of complex formation with other receptors, such as plexins in the case of semaphorins and the VEGF receptor, VEGFR2, resulting in enhanced signalling via some intracellular pathways. Recent findings indicate that NRPs may have important biological roles in other physiological and disease-related processes. In particular, NRPs are highly expressed in diverse tumour cell lines and human neoplasms and have been implicated in several biological processes regulating tumour growth in vivo, suggesting that NRP1 may be a future therapeutic target in cancer.
| Type: | Book chapter |
|---|---|
| Title: | Neuropilins: Role in Signalling, Angiogenesis and Disease |
| Location: | Switzerland |
| ISBN-13: | 9783318024807 |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1159/000354169 |
| Publisher version: | http://dx.doi.org/10.1159/000354169 |
| Language: | English |
| Additional information: | This is the peer-reviewed but unedited manuscript version of the following article: Zachary, I; (2014) Neuropilins: Role in Signalling, Angiogenesis and Disease. In: Marone, G and Granata, F, (eds.) Angiogenesis, Lymphangiogenesis and Clinical Implications. (pp. 37-70). Karger: Basel, Switzerland. Chemical Immunology and Allergy, Vol. 99. The final, published version is available at http://www.karger.com/?doi=10.1159/000354169. |
| Keywords: | Angiogenic Proteins, Animals, Cell Movement, Gene Expression Regulation, Humans, Lymphangiogenesis, Morphogenesis, Neoplasms, Neovascularization, Pathologic, Neovascularization, Physiologic, Neuropilins, Semaphorins, Signal Transduction |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Experimental and Translational Medicine |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/1422687 |
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