Klyubin, I; Nicoll, AJ; Khalili-Shirazi, A; Farmer, M; Canning, S; Mably, A; Linehan, J; ... Collinge, J; + view all Klyubin, I; Nicoll, AJ; Khalili-Shirazi, A; Farmer, M; Canning, S; Mably, A; Linehan, J; Brown, A; Wakeling, M; Brandner, S; Walsh, DM; Rowan, MJ; Collinge, J; - view fewer (2014) Peripheral Administration of a Humanized Anti-PrP Antibody Blocks Alzheimer's Disease Aβ Synaptotoxicity. J Neurosci , 34 (18) 6140 - 6145. 10.1523/JNEUROSCI.3526-13.2014.

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Abstract

Alzheimer's disease (AD) is associated with pathological assembly states of amyloid-β protein (Aβ). Aβ-related synaptotoxicity can be blocked by anti-prion protein (PrP) antibodies, potentially allowing therapeutic targeting of this aspect of AD neuropathogenesis. Here, we show that intravascular administration of a high-affinity humanized anti-PrP antibody to rats can prevent the plasticity-disrupting effects induced by exposure to soluble AD brain extract. These results provide an in vivo proof of principle for such a therapeutic strategy.

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