Li, C;
Wang, Z-H;
Yu, D-G;
Williams, GR;
(2014)
Tunable biphasic drug release from ethyl cellulose nanofibers fabricated using a modified coaxial electrospinning process.
Nanoscale Research Letters
, 9
, Article 258. 10.1186/1556-276X-9-258.
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Abstract
This manuscript reports a new type of drug-loaded core-shell nanofibers that provide tunable biphasic release of quercetin. The nanofibers were fabricated using a modified coaxial electrospinning process, in which a polyvinyl chloride (PVC)-coated concentric spinneret was employed. Poly (vinyl pyrrolidone) (PVP) and ethyl cellulose (EC) were used as the polymer matrices to form the shell and core parts of the nanofibers, respectively. Scanning and transmission electron microscopy demonstrated that the nanofibers had linear morphologies and core-shell structures. The quercetin was found to be present in the nanofibers in the amorphous physical status, on the basis of X-ray diffraction results. In vitro release profiles showed that the PVP shell very rapidly freed its drug cargo into the solution, while the EC core provided the succedent sustained release. Variation of the drug loading permitted the release profiles to be tuned.
| Type: | Article |
|---|---|
| Title: | Tunable biphasic drug release from ethyl cellulose nanofibers fabricated using a modified coaxial electrospinning process |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1186/1556-276X-9-258 |
| Publisher version: | http://dx.doi.org/10.1186/1556-276X-9-258 |
| Language: | English |
| Additional information: | © 2014 Li et al.; licensee Springer. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. PubMed ID: 24940180 |
| Keywords: | Modified coaxial electrospinning, Core-shell nanofibers, Tunable biphasic release, PVC-coated spinneret, Ethyl cellulose |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/1433722 |
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