Sommerlad, A;
Lee, J;
Warren, J;
Price, G;
(2014)
Neurodegenerative disorder masquerading as psychosis in a forensic psychiatry setting.
BMJ Case Reports
, 2014
10.1136/bcr-2013-203458.
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Abstract
A man presenting in his 50s, following conviction for a non-violent crime, to forensic psychiatric services, and then to a neuropsychiatry service with an unusual presentation of psychosis: second person auditory hallucinations, grandiose delusions and somatic delusions. Detailed collateral and family history revealed a background of progressive cognitive deficit and a family history of motor neuron disease. MRI of the brain revealed asymmetrical parieto-occipital volume loss and genetic testing demonstrated a pathogenic expansion of the chromosome 9 open reading frame 72 (C9ORF72) gene consistent with familial frontotemporal dementia caused by a hexanucleotide repeat expansion at C9ORF72, a recently discovered cause of familial frontotemporal dementia/motor neuron disease. This form of frontotemporal dementia should be considered as an important potential differential diagnosis for patients presenting with psychotic symptoms in later life, in whom a detailed family history and thorough cognitive assessment is essential.
| Type: | Article |
|---|---|
| Title: | Neurodegenerative disorder masquerading as psychosis in a forensic psychiatry setting |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1136/bcr-2013-203458 |
| Publisher version: | http://dx.doi.org/10.1136/bcr-2013-203458 |
| Language: | English |
| Additional information: | This article has been accepted for publication in BMJ Case Reports following peer review. The definitive copyedited, typeset version, Sommerlad, A; Lee, J; Warren, J; Price, G; (2014) Neurodegenerative disorder masquerading as psychosis in a forensic psychiatry setting. BMJ Case Reports, 2014, is available online at: http://dx.doi.org/10.1136/bcr-2013-203458. |
| Keywords: | Crime, Delusions, Diagnosis, Differential, Forensic Psychiatry, Frontotemporal Dementia, Hallucinations, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Mutation, Proteins, Psychotic Disorders |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/1452010 |
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