Meisel, S;
Beeken, RJ;
van Jaarsveld, CHM;
Wardle, J;
(2015)
Genetic susceptibility testing and readiness to control weight: results from a randomized controlled trial.
Obesity
, 23
(2)
pp. 305-312.
10.1002/oby.20958.
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Text (Article)
oby20958.pdf Available under License : See the attached licence file. Download (297kB) |
Abstract
Objective: To test the hypothesis that adding obesity gene feedback (FTO) to simple weight control advice at a life stage with raised risk of weight gain increases readiness to control weight. Methods: Individually-randomized controlled trial comparing the effect of: i) simple weight control advice plus FTO feedback (FA) and ii) simple weight control advice only (AO), on readiness to engage with weight control. Differences in stage of change by genotype, and differential weight control behaviors, were secondary outcomes. Results: Of 1016 participants randomized, only 279 completed follow-up; yielding 90% power to detect a small effect for readiness to control weight. As predicted, FA participants were more likely to be in the contemplation stage than AO participants (p=0.023). Participants receiving higher-risk genetic results were at a higher stage of change than controls (p=0.003), with a trend towards a higher stage of change than those getting lower-risk results (p=0.052). Lower-risk results did not decrease weight control intentions compared with controls (p=0.55). There were no group differences in adherence to recommended weight control behaviors (p=0.85). Conclusion: Adding FTO feedback to weight control advice enhanced readiness to control weight, without evidence for genetic determinism, but had no more effect on behavior than weight control advice alone.
Type: | Article |
---|---|
Title: | Genetic susceptibility testing and readiness to control weight: results from a randomized controlled trial |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.1002/oby.20958 |
Publisher version: | https://doi.org/10.1002/oby.20958 |
Language: | English |
Additional information: | © 2014 The Authors Obesity published by Wiley Periodicals, Inc. on behalf of The Obesity Society (TOS) This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/) |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Behavioural Science and Health |
URI: | https://discovery-pp.ucl.ac.uk/id/eprint/1454088 |
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