Dellett, M;
Sasai, N;
Nishide, K;
Becker, S;
Papadaki, V;
Limb, GA;
Moore, AT;
... Ohnuma, S; + view all
(2015)
Genetic background and light-dependent progression of photoreceptor cell degeneration in prominin-1 knockout mice.
Investigative Ophthalmology & Visual Science
, 56
(1)
164 - 176.
10.1167/iovs.14-15479.
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Abstract
Mutations in the Prominin-1 (Prom1) gene are known to cause retinitis pigmentosa and Stargardt disease, both of which are associated with progressive photoreceptor cell death. There are no effective therapies for either disorder. The aim of this study was to investigate the mechanism of the retinal degeneration in Prom1-deficient mouse models.
| Type: | Article |
|---|---|
| Title: | Genetic background and light-dependent progression of photoreceptor cell degeneration in prominin-1 knockout mice. |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1167/iovs.14-15479 |
| Publisher version: | http://dx.doi.org/10.1167/iovs.14-15479 |
| Language: | English |
| Keywords: | Prominin-1, Stargardt disease, fenretinide, light, modifier gene, photoreceptor degeneration, retinitis pigmentosa |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/1457168 |
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