Bučar, D-K;
Cockcroft, JK;
Elliott, JA;
Eddleston, MD;
Jones, W;
(2015)
Sonocrystallization yields monoclinic paracetamol with significantly improved compaction behavior.
Angewandte Chemie - International Edition
, 54
(1)
249 - 253.
10.1002/anie.201408894.
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Abstract
Ultrasound-assisted crystallization (sonocrystallization) was used to prepare a mixture of nano- and micrometersized crystals of the monoclinic form of paracetamol-a widely used analgesic known for its particularly problematic mechanical behavior under compression (i.e. poor tabletability). The nano- and micrometer-sized crystals yielded a powder which exhibits elastic moduli and bulk cohesions that are significantly higher than those observed in samples consisting of macro-meter- sized crystals, thus leading to enhanced tabletability without the use of excipients, particle coating, salt, or cocrystal formation. Experimental compaction and finite element analysis were utilized to rationalize the significantly improved compaction behavior of the monoclinic form of paracetamol.
| Type: | Article |
|---|---|
| Title: | Sonocrystallization yields monoclinic paracetamol with significantly improved compaction behavior |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/anie.201408894 |
| Publisher version: | http://dx.doi.org/10.1002/anie.201408894 |
| Language: | English |
| Additional information: | This is the peer reviewed version of the following article: Bučar, D-K; Cockcroft, JK; Elliott, JA; Eddleston, MD; Jones, W; (2015) Sonocrystallization yields monoclinic paracetamol with significantly improved compaction behavior. Angewandte Chemie - International Edition , 54 (1) 249 - 253., which has been published in final form at http:dx.doi.org/10.1002/anie.201408894.. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/1460977 |
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