Pike, KC;
Rose-Zerilli, MJ;
Osvald, EC;
Inskip, HM;
Godfrey, KM;
Crozier, SR;
Roberts, G;
... Southampton Women's Survey Study Group; + view all
(2011)
The relationship between infant lung function and the risk of wheeze in the preschool years.
Pediatric Pulmonology
, 46
(1)
pp. 75-82.
10.1002/ppul.21327.
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Abstract
RATIONALE: There is evidence that perinatal lung development predicts childhood wheeze. However, very few studies have examined whether preschool wheeze is associated with lower premorbid lung function in early infancy, and as yet there is no information relating atopic and non-atopic preschool wheeze to early lung development. OBJECTIVE: To examine the association between premorbid infant lung function and preschool wheeze, and to explore associations with atopic and non-atopic wheeze phenotypes. METHODS: Infant lung function was measured in 147 healthy term infants aged 5-14 weeks. Rapid thoracoabdominal compression was performed during tidal breathing and at raised volume to measure maximal expiratory flow at functional residual capacity (V' max FRC) and forced expiratory volume in 0.4 sec (FEV(0.4)). Atopic status was determined by skin prick testing at 3 years and wheeze ascertained from parental questionnaires (1 and 3 years). MEASUREMENTS AND MAIN RESULTS: Lower early infancy V' max FRC was associated with wheeze in both the first and third years of life (P=0.002 and 0.006, respectively). Lower early infancy FEV(0.4) was associated with wheeze in the first year (P=0.03). Compared to non-atopic children who did not wheeze, non-atopic children who wheezed in their third year of life had lower FEV(0.4) (P=0.02), while FEV(0.4) values of atopic children who wheezed were not significantly different (P=0.4). CONCLUSIONS: Lower premorbid infant lung function was present in infants who subsequently wheezed during the first and third years of life. Lower FEV(0.4) in early infancy was associated with non-atopic wheeze but not atopic wheeze at 3 years of age.
| Type: | Article |
|---|---|
| Title: | The relationship between infant lung function and the risk of wheeze in the preschool years |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/ppul.21327 |
| Publisher version: | http://dx.doi.org/10.1002/ppul.21327 |
| Language: | English |
| Additional information: | This is the peer reviewed version of the following article: Pike, KC; Rose-Zerilli, MJ; Osvald, EC; Inskip, HM; Godfrey, KM; Crozier, SR; Roberts, G; (2011) The relationship between infant lung function and the risk of wheeze in the preschool years. Pediatric Pulmonology, 46 (1) pp. 75-82. 10.1002/ppul.21327., which has been published in final form at: http://dx.doi.org/10.1002/ppul.21327. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving (http://olabout.wiley.com/WileyCDA/Section/id-820227.html#terms). |
| Keywords: | Asthma, Birth Weight, Child, Preschool, Female, Great Britain, Humans, Infant, Lung, Male, Prospective Studies, Respiratory Function Tests, Respiratory Sounds, Retrospective Studies, Risk, Skin Tests |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/1461054 |
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