Ishola, DA;
Andrews, N;
Waight, P;
Yung, CF;
Southern, J;
Bai, X;
Findlow, H;
... Miller, E; + view all
(2015)
Randomized Trial to Compare the Immunogenicity and Safety of a CRM or TT Conjugated Quadrivalent Meningococcal Vaccine in Teenagers who Received a CRM or TT Conjugated Serogroup C Vaccine at Preschool Age.
The Pediatric Infectious Disease Journal
, 34
(8)
pp. 865-874.
10.1097/INF.0000000000000750.
Preview |
Text
Ishola_Revised version - all sections combined .pdf Download (1MB) | Preview |
Abstract
Protection after meningococcal C (MenC) conjugate (MCC) vaccination in early childhood is short-lived. Boosting with a quadrivalent vaccine in teenage years, a high-risk period for MenC disease, should protect against additional serogroups but might compromise MenC response. The carrier protein in the primary MCC vaccine determines the response to MCC booster in toddlers, but the relationship between primary vaccine and booster given later is unclear. This study compared responses to a CRM-conjugated or tetanus toxoid (TT)-conjugated MenACWY vaccine in teenagers primed with different MCC vaccines at preschool age.
| Type: | Article |
|---|---|
| Title: | Randomized Trial to Compare the Immunogenicity and Safety of a CRM or TT Conjugated Quadrivalent Meningococcal Vaccine in Teenagers who Received a CRM or TT Conjugated Serogroup C Vaccine at Preschool Age |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1097/INF.0000000000000750 |
| Publisher version: | http://dx.doi.org/10.1097/INF.0000000000000750 |
| Language: | English |
| Additional information: | Copyright: Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. This manuscript version is made available under the CC-BY-NC 4.0 license http://creativecommons.org/licenses/by-nc/4.0/. Access may be initially be restricted by the publisher. |
| UCL classification: | UCL |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/1462469 |
Archive Staff Only
 |
View Item |
